Research Interest: Nanoscale Properties of Biological Materials

Nanoscale structure-property relationship of biomaterials. Biomimetics studies of natural materials. Deformation and failure mechanisms of nanostructured biomaterials.

Related Publications

A framework of computer vision-enhanced microfluidic approach for automated assessment of the transient sickling kinetics in sickle red blood cells

Y. Qiang, M. Xu, M. P. Pochron, M. Jupelli and M. Dao*, Frontiers in Physics, 12 (2024) 1331047.
Two-component macrophage model for active phagocytosis with pseudopod formation

S. Wang, S. Ma, H. Li, M. Dao, X. Li and G. E. Karniadakis, Biophysical Journal, 123 (2024) 1069-1084. (See BPS Blog)
High-Throughput Microfluidic Extraction of Platelet-free Plasma for MicroRNA and Extracellular Vesicle Analysis

S. Y. Leong, W. W. Lok, K. Y. Goh, H. B. Ong, H. M. Tay, C. Su, F. Kong, M. Upadya, W. Wang, E. Radnaa, R. Menon, M. Dao, R. Dalan, S. Suresh, D. W.-T. Lim and H. W. Hou, ACS Nano, 2024, 18, 6623-6637.
Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study

F. Kong*, M. Upadya, A.S.W. Wong, R. Dalan, M. Dao*, eLife, 13:RP92796, 2024.
Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease

Y. Zhang¹, Y. Qiang¹, H. Li, G. Li, L. Lu, M. Dao, G.E. Karniadakis, A.S. Popel, C. Zhao, PNAS Nexus, 3(2):pgae031, 2024.[¹Contributed equally.]
High-throughput single-cell assay for precise measurement of the intrinsic mechanical properties and shape characteristics of red blood cells

Q. Wei, Y. Xiong, Y. Ma, D. Liu, Y. Lu, S. Zhang, X. Wang, H. Huang, Y. Liu, M. Dao*, X. Gong*, Lab on a Chip, 24(2):305-316, 2024.
In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease

G. Li¹, Y. Qiang¹, H Li, X Li, M Dao*, GE Karniadakis*, Biophysical Journal, 122(12): 2590-2604, 2023. [¹Contributed equally.]
Evolution of surface area and membrane shear modulus of matured human red blood cells during mechanical fatigue

Q. Wei, X. Wang, C. Zhang, M. Dao, X, Gong, Scientific Reports, 13(1):8563, 2023.
Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening

M. Carucci, J. Duez, J. Tarning, I. García-Barbazán, A. Fricot-Monsinjon, A. Sissoko, L. Dumas, P. Gamallo, B. Beher, P. Amireault, M. Dussiot, M. Dao, M.V. Hull, C.W. McNamara, C. Roussel, P.A. Ndour, L.M. Sanz, F.J. Gamo, P. Buffet, Nature Communications 14 (2023) 1951.
Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

Y. Qiang, A. Sissoko, Z.L. Liu, T. Dong, F. Zheng, F. Kong, J.M. Higgins, G.E. Karniadakis, P.A. Buffet*, S. Suresh*, M. Dao*, Proc. Natl. Acad. Sci. USA, 120 (2023) e2217607120. (See MIT News Report, NTU News Report, and Technology Networks)
Microfluidics guided by deep learning for cancer immunotherapy screening

Z. Ao¹, H. Cai¹, Z. Wu, L. Hu, A. Nunez, Z. Zhou, H. Liu, M. Bondesson, X. Lu, X Lu, M. Dao*, F. Guo*, Proc. Natl. Acad. Sci. USA, 119 (2022) e2214569119. [¹Contributed equally.]
Microfluidic Size Exclusion Chromatography (μSEC) for Extracellular Vesicles and Plasma Protein Separation

S.Y. Leong, H.B. Ong, H.M. Tay, F. Kong, M. Upadya, L. Gong, M. Dao, R. Dalan, H.W. Hou*, Small, 18 (2022) 2104470. (Cover Article Volume 18, Issue 6; Februrary 10, 2022)
Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation

F. Zheng*, Y. Xiao, H. Liu, Y. Fan*, M. Dao*, Advanced Biology, 5 (2021) 2000024. (Cover Article June 2021)
Erythrocyte flow through the interendothelial slits of the splenic venous sinus

M. Dao, I. MacDonald, R.J. Asaro, Biomechanics and Modeling in Mechanobiology, 20 (2021) 2227-2245. (See SI Movie 1 & SI Movie 2)
In Vitro Assay for Single-cell Characterization of Impaired Deformability in Red Blood Cells under Recurrent Episodes of Hypoxia

Y. Qiang, J. Liu, M. Dao*, E Du*, Lab on a Chip, 21 (2021) 3458-3470.
Computational modeling of biomechanics and biorheology of heated red blood cells

Z.L. Liu¹*, H. Li¹*, Y. Qiang, P. Buffet, M. Dao, G.E Karniadakis*, Biophysical Journal, 120 (2021) 4663-4671. [¹Contributed equally.]
Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus

H.M. Tay, S.Y. Leong, X. Xu, F. Kong, M. Upadya, R. Dalan, C.Y. Tay, M. Dao, S. Suresh*, H.W. Hou*, Lab on a Chip, 21 (2021) 2511-2523. (Back-cover Article & Lab on a Chip HOT Articles 2021)
Characterization of the strain-rate–dependent mechanical response of single cell–cell junctions

A.M. Esfahani, J. Rosenbohm, B.T. Safa, N.V. Lavrik*, G. Minnick, Q. Zhou, F. Kong, X. Jin, E. Kim, Y. Liu, Y. Lu, J.Y. Lim, J.K. Wahl, M. Dao*, C. Huang*, R. Yang*, Proc. Natl. Acad. Sci. USA, 118 (2021) e2019347118. (See SI Movie 1, SI Movie 2, SI Movie 3, SI Movie 4 & News Phys.Org)
Quantifying Fibrinogen-Dependent Aggregation of Red Blood Cells in Type 2 Diabetes Mellitus

Y. Deng¹, D.P. Papageorgiou¹, X. Li, N. Perakakis, C.S. Mantzoros, M. Dao, G.E. Karniadakis, Biophysical Journal, 119 (2020) 900-912. [¹Contributed equally.]
Temperature-Induced Catch-Slip to Slip Bond Transit in Plasmodium falciparum-Infected Erythrocytes

Y.B. Lim, J. Thingna, F. Kong, M. Dao, J. Cao, C.T. Lim, Biophysical Journal, 118 (2020) 105-116.