Research Interest: Malaria & Sickle Cell Disease – Nanomechanics Logonanomechanics

Mechanobiology of malaria infected red blood cells and sickle cells. Development of high throughput diagnostic/therapeutic devices.

Related Publications

Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening

M. Carucci, J. Duez, J. Tarning, I. García-Barbazán, A. Fricot-Monsinjon, A. Sissoko, L. Dumas, P. Gamallo, B. Beher, P. Amireault, M. Dussiot, M. Dao, M.V. Hull, C.W. McNamara, C. Roussel, P.A. Ndour, L.M. Sanz, F.J. Gamo, P. Buffet, Nature Communications 14 (2023) 1951.
Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

Y. Qiang, A. Sissoko, Z.L. Liu, T. Dong, F. Zheng, F. Kong, J.M. Higgins, G.E. Karniadakis, P.A. Buffet*, S. Suresh*, M. Dao*, Proc. Natl. Acad. Sci. USA, 120 (2023) e2217607120. (See MIT News Report, NTU News Report, and Technology Networks)
Temperature-Induced Catch-Slip to Slip Bond Transit in Plasmodium falciparum-Infected Erythrocytes

Y.B. Lim, J. Thingna, F. Kong, M. Dao, J. Cao, C.T. Lim, Biophysical Journal, 118 (2020) 105-116.
Faster Sickling Kinetics and Sickle Cell Shape Evolution during Repeated Deoxygenation and Oxygenation Cycles

E. Du and M. Dao*, Experimental Mechanics, 59 (2019) 319-325.
Quantifying Shear-Induced Deformation and Detachment of Individual Adherent Sickle Red Blood Cells

Y. Deng, D.P. Papageorgiou, H.-Y. Chang, S.Z. Abidi, X. Li, M. Dao, G.E. Karniadakis, Biophysical Journal, 116 (2019) 360-371.
Simultaneous polymerization and adhesion under hypoxia in sickle cell disease

D.P. Papageorgiou, S.Z. Abidi, H.-Y. Chang, X.J. Li, G.J. Kato, G.E. Karniadakis, S. Suresh*, M. Dao*, Proc. Natl. Acad. Sci. USA, 115 (2018) 9473-9478. (See Supporting Information and SI Videos and Figures) (See MIT News Report, The Bioscientist, Xinhua News, and Tech Times)
Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders

H. Li, L. Lu, X. Li, P.A. Buffet, M. Dao*, G.E. Karniadakis*, S. Suresh*, Proc. Natl. Acad. Sci. USA, 115 (2018) 9574-9579. (See Supporting Information and SI Videos and Figures)
Febrile Temperature Elevates the Expression of Phosphatidylserine on Plasmodium falciparum (FCR3CSA) Infected Red Blood Cell Surface Leading to Increased Cytoadhesion

R. Zhang, R. Chandramohanadas*, C.T. Lim*, M. Dao*, Scientific Reports, 8 (2018) 15022. (See Supporting Information)
Automated, high-throughput, ex-vivo sickle red blood cell screening assay based on deep convolutional neural networks

M. Xu, D.P. Papageorgiou, S.Z. Abidi, M. Dao, H. Zhao and G.E. Karniadakis, PLoS Comput Biol, 13 (2017) e1005746. (See Supporting Information)
Patient-specific modeling of individual sickle cell behavior under transient hypoxia

X. Li, E Du, M. Dao*, S. Suresh and G.E. Karniadakis*, PLoS Comput Biol, 13 (2017) e1005426. (See Supporting Information)
Cellular Normoxic Biophysical Markers of Hydroxyurea Treatment in Sickle Cell Disease

P. Hosseini, S.Z. Abidi, E Du, D.P. Papageorgiou, Y. Choi, Y.-K. Park, J. Higgins, G.J. Kato, S. Suresh*, M. Dao*, Z. Yaqoob* and P.T.C. So, Proc. Natl. Acad. Sci. USA, 113 (2016) 9527-9532. (See Medical Xpress, News Medical, ScienceDaily, and CMU News Report)
Biomechanics of red blood cells in human spleen and consequences for physiology and disease

I.V. Pivkin, Z. Peng, G.E. Karniadakis, P.A. Buffet, M. Dao* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 113 (2016) 7804-7809. (See MIT News Report, CMU News Report, ScienceDaily Report, NIH Research Matters, News Medical, and Phys.org)
Biomechanics and biorheology of red blood cells in sickle cell anemia

X. Li, M. Dao, G. Lykotrafitis and G.E. Karniadakis, Journal of Biomechanics, 50 (2017) 34-41.
Patient-specific blood rheology in sickle-cell anaemia

X. Li, E. Du, H. Lei, Y.-H. Tang, M. Dao, S. Suresh and G.E. Karniadakis, Interface Focus, 6 (2016) 20150065.
A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609

R. Zhang, R. Suwanarusk, B. Malleret, B.M. Cooke, F. Nosten, Y.L. Lau, M. Dao, C.T. Lim, L. Renia, K.S. Tan and B. Russell, J. Infect. Dis., 213 (2016) 100-104.
De Novo Generated Human Red Blood Cells in Humanized Mice Support Plasmodium falciparum Infection

A. Amaladoss, Q. Chen, M. Liu, S.K. Dummler, M. Dao*, S. Suresh, J. Chen and P.R. Preiser*, PLoS ONE, 10 (2015) e0129825.
Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite

Y. Zhang, C. Huang, S. Kim, M. Golkaram, M.W.A. Dixon, L. Tilley, J. Li, S. Zhang* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 112 (2015) 6068-6073. (See CMU News Report)
Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stress

A. Sinha, T.T.T. Chu, M. Dao* and R. Chandramohanadas*, Scientific Reports, 5 (2015) 9768.
Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis

E Du, M. Diez-Silva, G.J. Kato, M. Dao* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 112 (2015) 1422-1427. (See MIT News Report and Video.)
Quantitative Biomechanics of Healthy and Diseased Human Red Blood Cells using Dielectrophoresis in a Microfluidic System

E Du, M. Dao* and S. Suresh, Extreme Mechanics Letters, 1 (2014) 35-41.