Research Interest: Nanoscale Properties of Biological Materials

Nanoscale structure-property relationship of biomaterials. Biomimetics studies of natural materials. Deformation and failure mechanisms of nanostructured biomaterials.

Related Publications

Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study

F. Kong*, M. Upadya, A.S.W. Wong, R. Dalan, M. Dao*, eLife, 13:RP92796, 2024.

Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease

Y. Zhang1, Y. Qiang1, H. Li, G. Li, L. Lu, M. Dao, G.E. Karniadakis, A.S. Popel, C. Zhao, PNAS Nexus, 3(2):pgae031, 2024.[1Contributed equally.]

High-throughput single-cell assay for precise measurement of the intrinsic mechanical properties and shape characteristics of red blood cells

Q. Wei, Y. Xiong, Y. Ma, D. Liu, Y. Lu, S. Zhang, X. Wang, H. Huang, Y. Liu, M. Dao*, X. Gong*, Lab on a Chip, 24(2):305-316, 2024.

In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease

G. Li1, Y. Qiang1, H Li, X Li, M Dao*, GE Karniadakis*, Biophysical Journal, 122(12): 2590-2604, 2023. [1Contributed equally.]

Evolution of surface area and membrane shear modulus of matured human red blood cells during mechanical fatigue

Q. Wei, X. Wang, C. Zhang, M. Dao, X, Gong, Scientific Reports, 13(1):8563, 2023.

Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening

M. Carucci, J. Duez, J. Tarning, I. García-Barbazán, A. Fricot-Monsinjon, A. Sissoko, L. Dumas, P. Gamallo, B. Beher, P. Amireault, M. Dussiot, M. Dao, M.V. Hull, C.W. McNamara, C. Roussel, P.A. Ndour, L.M. Sanz, F.J. Gamo, P. Buffet, Nature Communications 14 (2023) 1951.

Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

Y. Qiang, A. Sissoko, Z.L. Liu, T. Dong, F. Zheng, F. Kong, J.M. Higgins, G.E. Karniadakis, P.A. Buffet*, S. Suresh*, M. Dao*, Proc. Natl. Acad. Sci. USA, 120 (2023) e2217607120. (See MIT News Report, NTU News Report, and Technology Networks)

Microfluidics guided by deep learning for cancer immunotherapy screening

Z. Ao1, H. Cai1, Z. Wu, L. Hu, A. Nunez, Z. Zhou, H. Liu, M. Bondesson, X. Lu, X Lu, M. Dao*, F. Guo*, Proc. Natl. Acad. Sci. USA, 119 (2022) e2214569119. [1Contributed equally.]

Microfluidic Size Exclusion Chromatography (μSEC) for Extracellular Vesicles and Plasma Protein Separation

S.Y. Leong, H.B. Ong, H.M. Tay, F. Kong, M. Upadya, L. Gong, M. Dao, R. Dalan, H.W. Hou*, Small, 18 (2022) 2104470. (Cover Article Volume 18, Issue 6; Februrary 10, 2022)

Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation

F. Zheng*, Y. Xiao, H. Liu, Y. Fan*, M. Dao*, Advanced Biology, 5 (2021) 2000024. (Cover Article June 2021)

Erythrocyte flow through the interendothelial slits of the splenic venous sinus

M. Dao, I. MacDonald, R.J. Asaro, Biomechanics and Modeling in Mechanobiology, 20 (2021) 2227-2245. (See SI Movie 1 & SI Movie 2)

In Vitro Assay for Single-cell Characterization of Impaired Deformability in Red Blood Cells under Recurrent Episodes of Hypoxia

Y. Qiang, J. Liu, M. Dao*, E Du*, Lab on a Chip, 21 (2021) 3458-3470.

Computational modeling of biomechanics and biorheology of heated red blood cells

Z.L. Liu1*, H. Li1*, Y. Qiang, P. Buffet, M. Dao, G.E Karniadakis*, Biophysical Journal, 120 (2021) 4663-4671. [1Contributed equally.]

Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus

H.M. Tay, S.Y. Leong, X. Xu, F. Kong, M. Upadya, R. Dalan, C.Y. Tay, M. Dao, S. Suresh*, H.W. Hou*, Lab on a Chip, 21 (2021) 2511-2523. (Back-cover Article & Lab on a Chip HOT Articles 2021)

Characterization of the strain-rate–dependent mechanical response of single cell–cell junctions

A.M. Esfahani, J. Rosenbohm, B.T. Safa, N.V. Lavrik*, G. Minnick, Q. Zhou, F. Kong, X. Jin, E. Kim, Y. Liu, Y. Lu, J.Y. Lim, J.K. Wahl, M. Dao*, C. Huang*, R. Yang*, Proc. Natl. Acad. Sci. USA, 118 (2021) e2019347118. (See SI Movie 1, SI Movie 2, SI Movie 3, SI Movie 4 & News Phys.Org)

Quantifying Fibrinogen-Dependent Aggregation of Red Blood Cells in Type 2 Diabetes Mellitus

Y. Deng1, D.P. Papageorgiou1, X. Li, N. Perakakis, C.S. Mantzoros, M. Dao, G.E. Karniadakis, Biophysical Journal, 119 (2020) 900-912. [1Contributed equally.]

Temperature-Induced Catch-Slip to Slip Bond Transit in Plasmodium falciparum-Infected Erythrocytes

Y.B. Lim, J. Thingna, F. Kong, M. Dao, J. Cao, C.T. Lim, Biophysical Journal, 118 (2020) 105-116.

Mechanical fatigue of human red blood cells

Y. Qiang, J. Liu, M. Dao*, S. Suresh*, E. Du*, Proc. Natl. Acad. Sci. USA, 116 (2019) 19828-19834.

Faster Sickling Kinetics and Sickle Cell Shape Evolution during Repeated Deoxygenation and Oxygenation Cycles

E. Du and M. Dao*, Experimental Mechanics, 59 (2019) 319-325.

Quantifying Shear-Induced Deformation and Detachment of Individual Adherent Sickle Red Blood Cells

Y. Deng, D.P. Papageorgiou, H.-Y. Chang, S.Z. Abidi, X. Li, M. Dao, G.E. Karniadakis, Biophysical Journal, 116 (2019) 360-371.

Simultaneous polymerization and adhesion under hypoxia in sickle cell disease

D.P. Papageorgiou, S.Z. Abidi, H.-Y. Chang, X.J. Li, G.J. Kato, G.E. Karniadakis, S. Suresh*, M. Dao*, Proc. Natl. Acad. Sci. USA, 115 (2018) 9473-9478. (See Supporting Information and SI Videos and Figures) (See MIT News Report, The Bioscientist, Xinhua News, and Tech Times)

Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders

H. Li, L. Lu, X. Li, P.A. Buffet, M. Dao*, G.E. Karniadakis*, S. Suresh*, Proc. Natl. Acad. Sci. USA, 115 (2018) 9574-9579. (See Supporting Information and SI Videos and Figures)

Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation

M.X. Wu, P.H. Huang, R. Zhang, Z.M. Mao, C.Y. Chen, G. Kemeny, P. Li, A.V. Lee, R. Gyanchandani, A.J. Armstrong, M. Dao*, S. Suresh, T.J. Huang*, Small (Featured Cover Article), 14 (2018) 1801131. (See Supporting Information and Cover Picture)

Febrile Temperature Elevates the Expression of Phosphatidylserine on Plasmodium falciparum (FCR3CSA) Infected Red Blood Cell Surface Leading to Increased Cytoadhesion

R. Zhang, R. Chandramohanadas*, C.T. Lim*, M. Dao*, Scientific Reports, 8 (2018) 15022. (See Supporting Information)

Cytoskeleton Remodeling Induces Membrane Stiffness and Stability Changes of Maturing Reticulocytes

H. Li, J. Yang, T.T. Chu, R. Naidu, L. Lu, R. Chandramohanadas, M. Dao, G.E. Karniadakis, Biophysical Journal, 114 (2018) 2014-2023.

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

M. Wu, Y. Ouyang, Z. Wang, R. Zhang, P.-H. Huang, C. Chen, H. Li, P. Li, D. Quinn, M. Dao*, S. Suresh*, Y. Sadovsky* and T.J. Huang*, Proc. Natl. Acad. Sci. USA, 114 (2017) 10584-10589. (See MIT News Report and Video)

Automated, high-throughput, ex-vivo sickle red blood cell screening assay based on deep convolutional neural networks

M. Xu, D.P. Papageorgiou, S.Z. Abidi, M. Dao, H. Zhao and G.E. Karniadakis, PLoS Comput Biol, 13 (2017) e1005746. (See Supporting Information)

Soft tubular microfluidics for 2D and 3D applications

W. Xi, F. Kong, J.C. Yeo, L. Yu, S. Sonam, M. Dao, X. Gong and C.T. Lim, Proc. Natl. Acad. Sci. USA, 114 (2017) 10590–10595.

Patient-specific modeling of individual sickle cell behavior under transient hypoxia

X. Li, E Du, M. Dao*, S. Suresh and G.E. Karniadakis*, PLoS Comput Biol, 13 (2017) e1005426. (See Supporting Information)

Formation and size distribution of self-assembled vesicles

C. Huang, D. Quinn, Y. Sadovsky, S. Suresh* and K.J. Hsia*, Proc. Natl. Acad. Sci. USA, 114 (2017) 2910-2915. (See CMU News Report, and Phys.org)

Biomechanics and biorheology of red blood cells in sickle cell anemia

X. Li, M. Dao, G. Lykotrafitis and G.E. Karniadakis, Journal of Biomechanics, 50 (2017) 34-41.

Cellular Normoxic Biophysical Markers of Hydroxyurea Treatment in Sickle Cell Disease

P. Hosseini, S.Z. Abidi, E Du, D.P. Papageorgiou, Y. Choi, Y.-K. Park, J. Higgins, G.J. Kato, S. Suresh*, M. Dao*, Z. Yaqoob* and P.T.C. So, Proc. Natl. Acad. Sci. USA, 113 (2016) 9527-9532. (See Medical Xpress, News Medical, ScienceDaily, and CMU News Report)

Biomechanics of red blood cells in human spleen and consequences for physiology and disease

I.V. Pivkin, Z. Peng, G.E. Karniadakis, P.A. Buffet, M. Dao* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 113 (2016) 7804-7809. (See MIT News Report, CMU News Report, ScienceDaily Report, NIH Research Matters, News Medical, and Phys.org)

Studies of chain substitution caused sub-fibril level differences in stiffness and ultrastructure of wildtype and oim/oim collagen fibers using multifrequency-AFM and molecular modeling

T. Li, S.-W. Chang, N. Rodriguez-Florez, M.J. Buehler, S. Shefelbine*, M. Dao*, K. Zeng*, Biomaterials, 107 (2016) 15-22. (See Supporting Information)

Exposure of Stored Packed Erythrocytes to NO Prevents Transfusion-associated Pulmonary Hypertension

S. Muenster, A. Beloiartsev, B. Yu, E Du, S. Abidi, M. Dao, G. Fabry, J.A. Graw, M. Wepler, R. Malhotra, B.O. Fernandez, M. Feelisch, K.D. Bloch, D.B. Bloch and W.M. Zapol, Anesthesiology, 125 (2016) 952-963. (See Supporting Information and This Month in Anesthesiology|November 2016)

Patient-specific blood rheology in sickle-cell anaemia

X. Li, E. Du, H. Lei, Y.-H. Tang, M. Dao, S. Suresh and G.E. Karniadakis, Interface Focus, 6 (2016) 20150065.

A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609

R. Zhang, R. Suwanarusk, B. Malleret, B.M. Cooke, F. Nosten, Y.L. Lau, M. Dao, C.T. Lim, L. Renia, K.S. Tan and B. Russell, J. Infect. Dis., 213 (2016) 100-104.

Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite

Y. Zhang, C. Huang, S. Kim, M. Golkaram, M.W.A. Dixon, L. Tilley, J. Li, S. Zhang* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 112 (2015) 6068-6073. (See CMU News Report)

Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stress

A. Sinha, T.T.T. Chu, M. Dao* and R. Chandramohanadas*, Scientific Reports, 5 (2015) 9768.

Acoustic separation of circulating tumor cells

P. Li, Z. Mao, Z. Peng, L. Zhou, Y. Chen, P.-H. Huang, C.I. Truica, J.J. Drabick, W.S. El-Deiry, M. Dao*, S. Suresh* and T.J. Huang*, Proc. Natl. Acad. Sci. USA, 112 (2015) 4970-4975. (See MIT News Report and Video; PNAS In This Issue April 21, 2015.)

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis

E Du, M. Diez-Silva, G.J. Kato, M. Dao* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 112 (2015) 1422-1427. (See MIT News Report and Video.)

Fracture mode control: a bio-inspired strategy to combat catastrophic damage

H. Yao*, Z. Xie, C. He and M. Dao, Scientific Reports, 5 (2015) 8011.

Quantitative Biomechanics of Healthy and Diseased Human Red Blood Cells using Dielectrophoresis in a Microfluidic System

E Du, M. Dao* and S. Suresh, Extreme Mechanics Letters, 1 (2014) 35-41.

Cell separation using tilted-angle standing surface acoustic waves

X. Ding, Z. Peng, S.C.S. Lin, M. Geri, S. Li, P. Li, Y. Chen, M. Dao*, S. Suresh* and T.J. Huang*, Proc. Natl. Acad. Sci. USA, 111 (2014) 12992-12997. (See MIT News Report and Video.)

Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species

R. Chandramohanadas, Basappa, B. Russell, K. Liew, Y.H. Yau, A. Chong, M. Liu, K. Gunalan, R. Raman, L. Renia, F. Nosten, S.G. Shochat, M. Dao*, R. Sasisekharan, S. Suresh and P. Preiser*, J. Infect. Dis., 210 (2014) 1616-1626.

Probing red blood cell mechanics, rheology and dynamics with a two-component multiscale model

X. Li, Z. Peng, H. Lei, M. Dao and G.E. Karniadakis*, Phil. Trans. R. Soc. A, 372 (2014) 20130389.

In Vivo Splenic Clearance Correlates with In Vitro Deformability of Red Blood Cells from Plasmodium yoelii-Infected Mice

S. Huang, A. Amaladoss, M. Liu, H. Chen, R. Zhang, P.R. Preiser, M. Dao* and J. Han*, Infection and Immunity, 82 (2014) 2532-2541.

Computational Biorheology of Human Blood Flow in Health and Disease

D.A. Fedosov, M. Dao, G.E. Karniadakis* and S. Suresh, Annals of Biomedical Engineering (Review Article), 42 (2014) 368-387.

High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography

K. Kim, H.-O. Yoon, M. Diez-Silva, M. Dao, R.R. Dasari and Y.-K. Park*, J. Biomed. Opt., 19 (2014) 011005.

Electric Impedance Microflow Cytometry for Characterization of Cell Disease States

E. Du, S. Ha, M. Diez-Silva, M. Dao*, S. Suresh and A.P. Chandrakasan*, Lab on a Chip, 13 (2013) 3903-3909. (See MIT News Report.)

Lipid bilayer and cytoskeletal interactions in a red blood cell

Z. Peng, X. Li, I.V. Pivkin, M. Dao, G.E. Karniadakis and S. Suresh*, Proc. Natl. Acad. Sci. USA, 110 (2013) 13356-13361.

Probing the Cytoadherence of Malaria Infected Red Blood Cells under Flow

X. Xu, A.K. Efremov, A. Li, L. Lai, M. Dao, C.T. Lim* and J. Cao*, PLoS ONE, 8 (2013) e64763.

Cytoadherence of erythrocytes invaded by Plasmodium falciparum: Quantitative contact-probing of a human malaria receptor

P.A. Carvalho, M. Diez-Silva, H. Chen, M. Dao* and S. Suresh, Acta Biomaterialia, 9 (2013) 6349-6359.

Dynamic deformability of Plasmodium falciparum-infected erythrocytes exposed to artesunate in vitro

S. Huang, A. Undisz, M. Diez-Silva, H. Bow, M. Dao* and J. Han*, Integrative Biology, 5 (2013) 414-422.

Probing circulating tumor cells in microfluidics

P. Li, Z.S. Stratton, M. Dao, J. Ritz and T.J. Huang*, Lab on a Chip, 13 (2013) 602-609.
==> See Lab on a Chip Blog about this article

Orientation and Size Dependent Mechanical Modulation within Individual Secondary Osteons in Cortical Bone Tissue

D. Carnelli*, P. Vena, M. Dao, C. Ortiz and R. Contro, J. R. Soc. Interface, 10 (2013) 20120953.

Bio-inspired interfacial strengthening strategy through geometrically interlocking designs

Y. Zhang, H. Yao, C. Ortiz, J. Xu and M. Dao, J. Mech. Behav. Biomed. Mater., 15 (2012) 70-77.

Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells

M. Diez-Silva, Y.-K. Park, S. Huang, H. Bow, O. Mercereau-Puijalon, G. Deplaine, C. Lavazec, S. Perrot, S. Bonnefoy, M.S. Feld, J. Han, M. Dao and S. Suresh, Scientific Reports (Nature.com/srep), 2 (2012) 614.
==> See MIT News Report, ScienceDaily News

Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient

H.-S. Byun, T.R. Hillman, J.M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R.R. Dasari, S. Suresh and Y.-K. Park, Acta Biomaterialia, 2012, in press. (See supplementary materials.)

Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum

M. Aingaran, R. Zhang, S.K.Y. Law, Z. Peng, A. Undisz, E. Meyer, M. Diez-Silva, T.A. Burke, T. Spielmann, C.-T. Lim, S. Suresh, M. Dao and M. Marti, Cellular Microbiology (July 2012 Editor’s Choice), 14 (2012) 983-993. doi:10.1111/j.1462-5822.2012.01786.x

Continuum modeling of neuronal cell under blast loading

A. Jerusalem and M. Dao, Acta Biomaterialia, 8 (2012) 3360-3371. (See supplementary materials.)

Anisotropic light scattering of individual sickle red blood cells

Y. Kim, J.M. Higgins, R.R. Dasari, S. Suresh and Y.-K. Park, Journal of Biomedical Optics Letters, 17 (2012) 040501.

Size-dependent heterogeneity benefits the mechanical performance of bone

H. Yao, M. Dao, D. Carnelli, K. Tai and C. Ortiz, J. Mech. Phys. Solids, 59 (2011) 64-74.

Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria

Dmitry A. Fedosov, Huan Lei, Bruce Caswell, Subra Suresh, George E. Karniadakis, PLoS Comput Biol 2011, 7(12): e1002270. doi:10.1371/journal.pcbi.1002270

Biophysics of Malarial Parasite Exit from Infected Erythrocytes

R. Chandramohanadas, Y.-K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C.-T. Lim, P.R. Preiser and S. Suresh, PLoS ONE2011, 6(6): e20869. doi:10.1371/journal.pone.0020869 (supplementary materials)

Combined simulation and experimental study of large deformation of red blood cells in microfluidic systems

D.J. Quinn, I. Pivkin, S.Y. Wong, K.-H. Chiam, M. Dao, G.E. Karniadakis and S. Suresh, Annals of Biomedical Engineering, 39 (2011) 1041-1050. (supplementary materials)

A microfabricated deformability-based flow cytometer with application to malaria

H. Bow, I.V. Pivkin, M. Diez-Silva, S.J. Goldfless, M. Dao, J.C. Niles, S. Suresh and J. Han, Lab on a Chip, 11 (2011) 1065-1073.

Quantifying the biophysical characteristics of Plasmodium-falciparum-parasitized red blood cells in microcirculation

D.A. Fedosov, B. Caswell, S. Suresh and G.E. Karniadakis, PNAS, 108 (2011) 35-39. (supplementary materials; movie #1; movie #2; movie #3)

Protection mechanisms of the iron-plated armor of a deep-sea hydrothermal vent gastropod

H. Yao, M. Dao, T. Imholt, J. Huang, K. Wheeler, S. Suresh and C. Ortiz, PNAS, 107 (2010) 987-992. (supplementary materials)
==> see MIT News Report

Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease

M. Diez-Silva, M. Dao, J. Han, C.-T. Lim and S. Suresh, MRS Bulletin, 35 (2010) 382-388.
==> see MRS Bulletin Cover Image

Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

Y.-K. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh and M.S. Feld, Journal of Biomedical Optics 2010, 15(2): 020506.

Metabolic remodeling of the human red blood cell membrane

Y.K. Park, C.A. Best, T. Auth, N. Gov, S.A. Safran, G. Popescu, S. Suresh and M.S. Feld, PNAS, 107 (2010) 1289-1294. (supplementary materials)
==> see PNAS Cover Image

Size-Dependent Endocytosis of Nanoparticles

S. Zhang, J. Li, G. Lykotrafitis, G. Bao and S. Suresh, Advanced Materials, 21 (2009) 419-424.

Nanoscale Heterogeneity Promotes Energy Dissipation in Bone

K. Tai, M. Dao, S. Suresh, A. Palazoglu and C. Ortiz, Nature Materials, 6, 454-462, 2007.
==> see MIT News Report & MIT Tech Talk Article & Science Daily Report

Biomechanics and biophysics of cancer cells

S. Suresh, Acta Biomaterialia, 3, 413–438, 2007.

NEWS & VIEWS - Nanomedicine: Elastic clues in cancer detection

S. Suresh., Nature Nanotechnology, 2007, doi:10.1038/nnano.2007.397.
(See the original paper here: pdf)

Cytoskeletal dynamics of human erythrocyte

J. Li, G. Lykotrafitis, M. Dao and S. Suresh, PNAS, 104(12) 4937-4942, 2007
==> see MIT News Report & MIT Tech Talk Article & MRS Materials360

Molecularly based analysis of deformation of spectrin network and human erythrocyte

M. Dao, J. Li and S. Suresh, Mat Sci Eng C (26) 1232-1244, 2006.

Spectrin-Level Modeling of the Cytoskeleton and Optical Tweezers Stretching of the Erythrocyte

J. Li, M. Dao, C.T. Lim and S. Suresh, Biophysical Journal, 88, 3707-3719, 2005.

Cell and molecular mechanics of biological materials

G. Bao and S. Suresh, Nature Materials, 2, 715-725, 2003.