Research Interest: Malaria & Sickle Cell Disease

Mechanobiology of malaria infected red blood cells and sickle cells. Development of high throughput diagnostic/therapeutic devices.

Related Publications

Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening

M. Carucci, J. Duez, J. Tarning, I. García-Barbazán, A. Fricot-Monsinjon, A. Sissoko, L. Dumas, P. Gamallo, B. Beher, P. Amireault, M. Dussiot, M. Dao, M.V. Hull, C.W. McNamara, C. Roussel, P.A. Ndour, L.M. Sanz, F.J. Gamo, P. Buffet, Nature Communications 14 (2023) 1951.

Microfluidic study of retention and elimination of abnormal red blood cells by human spleen with implications for sickle cell disease

Y. Qiang, A. Sissoko, Z.L. Liu, T. Dong, F. Zheng, F. Kong, J.M. Higgins, G.E. Karniadakis, P.A. Buffet*, S. Suresh*, M. Dao*, Proc. Natl. Acad. Sci. USA, 120 (2023) e2217607120. (See MIT News Report, NTU News Report, and Technology Networks)

Temperature-Induced Catch-Slip to Slip Bond Transit in Plasmodium falciparum-Infected Erythrocytes

Y.B. Lim, J. Thingna, F. Kong, M. Dao, J. Cao, C.T. Lim, Biophysical Journal, 118 (2020) 105-116.

Faster Sickling Kinetics and Sickle Cell Shape Evolution during Repeated Deoxygenation and Oxygenation Cycles

E. Du and M. Dao*, Experimental Mechanics, 59 (2019) 319-325.

Quantifying Shear-Induced Deformation and Detachment of Individual Adherent Sickle Red Blood Cells

Y. Deng, D.P. Papageorgiou, H.-Y. Chang, S.Z. Abidi, X. Li, M. Dao, G.E. Karniadakis, Biophysical Journal, 116 (2019) 360-371.

Simultaneous polymerization and adhesion under hypoxia in sickle cell disease

D.P. Papageorgiou, S.Z. Abidi, H.-Y. Chang, X.J. Li, G.J. Kato, G.E. Karniadakis, S. Suresh*, M. Dao*, Proc. Natl. Acad. Sci. USA, 115 (2018) 9473-9478. (See Supporting Information and SI Videos and Figures) (See MIT News Report, The Bioscientist, Xinhua News, and Tech Times)

Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders

H. Li, L. Lu, X. Li, P.A. Buffet, M. Dao*, G.E. Karniadakis*, S. Suresh*, Proc. Natl. Acad. Sci. USA, 115 (2018) 9574-9579. (See Supporting Information and SI Videos and Figures)

Febrile Temperature Elevates the Expression of Phosphatidylserine on Plasmodium falciparum (FCR3CSA) Infected Red Blood Cell Surface Leading to Increased Cytoadhesion

R. Zhang, R. Chandramohanadas*, C.T. Lim*, M. Dao*, Scientific Reports, 8 (2018) 15022. (See Supporting Information)

Automated, high-throughput, ex-vivo sickle red blood cell screening assay based on deep convolutional neural networks

M. Xu, D.P. Papageorgiou, S.Z. Abidi, M. Dao, H. Zhao and G.E. Karniadakis, PLoS Comput Biol, 13 (2017) e1005746. (See Supporting Information)

Patient-specific modeling of individual sickle cell behavior under transient hypoxia

X. Li, E Du, M. Dao*, S. Suresh and G.E. Karniadakis*, PLoS Comput Biol, 13 (2017) e1005426. (See Supporting Information)

Biomechanics and biorheology of red blood cells in sickle cell anemia

X. Li, M. Dao, G. Lykotrafitis and G.E. Karniadakis, Journal of Biomechanics, 50 (2017) 34-41.

Cellular Normoxic Biophysical Markers of Hydroxyurea Treatment in Sickle Cell Disease

P. Hosseini, S.Z. Abidi, E Du, D.P. Papageorgiou, Y. Choi, Y.-K. Park, J. Higgins, G.J. Kato, S. Suresh*, M. Dao*, Z. Yaqoob* and P.T.C. So, Proc. Natl. Acad. Sci. USA, 113 (2016) 9527-9532. (See Medical Xpress, News Medical, ScienceDaily, and CMU News Report)

Biomechanics of red blood cells in human spleen and consequences for physiology and disease

I.V. Pivkin, Z. Peng, G.E. Karniadakis, P.A. Buffet, M. Dao* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 113 (2016) 7804-7809. (See MIT News Report, CMU News Report, ScienceDaily Report, NIH Research Matters, News Medical, and Phys.org)

Patient-specific blood rheology in sickle-cell anaemia

X. Li, E. Du, H. Lei, Y.-H. Tang, M. Dao, S. Suresh and G.E. Karniadakis, Interface Focus, 6 (2016) 20150065.

A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609

R. Zhang, R. Suwanarusk, B. Malleret, B.M. Cooke, F. Nosten, Y.L. Lau, M. Dao, C.T. Lim, L. Renia, K.S. Tan and B. Russell, J. Infect. Dis., 213 (2016) 100-104.

De Novo Generated Human Red Blood Cells in Humanized Mice Support Plasmodium falciparum Infection

A. Amaladoss, Q. Chen, M. Liu, S.K. Dummler, M. Dao*, S. Suresh, J. Chen and P.R. Preiser*, PLoS ONE, 10 (2015) e0129825.

Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite

Y. Zhang, C. Huang, S. Kim, M. Golkaram, M.W.A. Dixon, L. Tilley, J. Li, S. Zhang* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 112 (2015) 6068-6073. (See CMU News Report)

Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stress

A. Sinha, T.T.T. Chu, M. Dao* and R. Chandramohanadas*, Scientific Reports, 5 (2015) 9768.

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis

E Du, M. Diez-Silva, G.J. Kato, M. Dao* and S. Suresh*, Proc. Natl. Acad. Sci. USA, 112 (2015) 1422-1427. (See MIT News Report and Video.)

Quantitative Biomechanics of Healthy and Diseased Human Red Blood Cells using Dielectrophoresis in a Microfluidic System

E Du, M. Dao* and S. Suresh, Extreme Mechanics Letters, 1 (2014) 35-41.

Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species

R. Chandramohanadas, Basappa, B. Russell, K. Liew, Y.H. Yau, A. Chong, M. Liu, K. Gunalan, R. Raman, L. Renia, F. Nosten, S.G. Shochat, M. Dao*, R. Sasisekharan, S. Suresh and P. Preiser*, J. Infect. Dis., 210 (2014) 1616-1626.

In Vivo Splenic Clearance Correlates with In Vitro Deformability of Red Blood Cells from Plasmodium yoelii-Infected Mice

S. Huang, A. Amaladoss, M. Liu, H. Chen, R. Zhang, P.R. Preiser, M. Dao* and J. Han*, Infection and Immunity, 82 (2014) 2532-2541.

Human Natural Killer Cells Control Plasmodium falciparum Infection by Eliminating Infected Red Blood Cells

Q. Chen, A. Amaladoss, W. Ye, F. Kong, M. Liu, S. Dummler, L.H. Wong, H.L. Loo, S.Q Tan, T.C. Tan, M. Dao*, S. Suresh*, P.R. Preiser* and J. Chen*, Proc. Natl. Acad. Sci. USA, 111 (2014) 1479-1484. (See MIT News Report.)

Computational Biorheology of Human Blood Flow in Health and Disease

D.A. Fedosov, M. Dao, G.E. Karniadakis* and S. Suresh, Annals of Biomedical Engineering (Review Article), 42 (2014) 368-387.

High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography

K. Kim, H.-O. Yoon, M. Diez-Silva, M. Dao, R.R. Dasari and Y.-K. Park*, J. Biomed. Opt., 19 (2014) 011005.

Electric Impedance Microflow Cytometry for Characterization of Cell Disease States

E. Du, S. Ha, M. Diez-Silva, M. Dao*, S. Suresh and A.P. Chandrakasan*, Lab on a Chip, 13 (2013) 3903-3909. (See MIT News Report.)

Lipid bilayer and cytoskeletal interactions in a red blood cell

Z. Peng, X. Li, I.V. Pivkin, M. Dao, G.E. Karniadakis and S. Suresh*, Proc. Natl. Acad. Sci. USA, 110 (2013) 13356-13361.

Probing the Cytoadherence of Malaria Infected Red Blood Cells under Flow

X. Xu, A.K. Efremov, A. Li, L. Lai, M. Dao, C.T. Lim* and J. Cao*, PLoS ONE, 8 (2013) e64763.

Cytoadherence of erythrocytes invaded by Plasmodium falciparum: Quantitative contact-probing of a human malaria receptor

P.A. Carvalho, M. Diez-Silva, H. Chen, M. Dao* and S. Suresh, Acta Biomaterialia, 9 (2013) 6349-6359.

Dynamic deformability of Plasmodium falciparum-infected erythrocytes exposed to artesunate in vitro

S. Huang, A. Undisz, M. Diez-Silva, H. Bow, M. Dao* and J. Han*, Integrative Biology, 5 (2013) 414-422.

Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells

M. Diez-Silva, Y.-K. Park, S. Huang, H. Bow, O. Mercereau-Puijalon, G. Deplaine, C. Lavazec, S. Perrot, S. Bonnefoy, M.S. Feld, J. Han, M. Dao and S. Suresh, Scientific Reports (Nature.com/srep), 2 (2012) 614.
==> See MIT News Report, ScienceDaily News

Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum

M. Aingaran, R. Zhang, S.K.Y. Law, Z. Peng, A. Undisz, E. Meyer, M. Diez-Silva, T.A. Burke, T. Spielmann, C.-T. Lim, S. Suresh, M. Dao and M. Marti, Cellular Microbiology (July 2012 Editor’s Choice), 14 (2012) 983-993. doi:10.1111/j.1462-5822.2012.01786.x

Anisotropic light scattering of individual sickle red blood cells

Y. Kim, J.M. Higgins, R.R. Dasari, S. Suresh and Y.-K. Park, Journal of Biomedical Optics Letters, 17 (2012) 040501.

Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria

Dmitry A. Fedosov, Huan Lei, Bruce Caswell, Subra Suresh, George E. Karniadakis, PLoS Comput Biol 2011, 7(12): e1002270. doi:10.1371/journal.pcbi.1002270

Biophysics of Malarial Parasite Exit from Infected Erythrocytes

R. Chandramohanadas, Y.-K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C.-T. Lim, P.R. Preiser and S. Suresh, PLoS ONE2011, 6(6): e20869. doi:10.1371/journal.pone.0020869 (supplementary materials)

Measuring single-cell density

W.H. Grover, A.K. Bryan, M. Diez-Silva, S. Suresh, J.M. Higgins and S.R. Manalis, PNAS, 108 (2011) 10992-10996.

Combined simulation and experimental study of large deformation of red blood cells in microfluidic systems

D.J. Quinn, I. Pivkin, S.Y. Wong, K.-H. Chiam, M. Dao, G.E. Karniadakis and S. Suresh, Annals of Biomedical Engineering, 39 (2011) 1041-1050. (supplementary materials)

A microfabricated deformability-based flow cytometer with application to malaria

H. Bow, I.V. Pivkin, M. Diez-Silva, S.J. Goldfless, M. Dao, J.C. Niles, S. Suresh and J. Han, Lab on a Chip, 11 (2011) 1065-1073.

Quantifying the biophysical characteristics of Plasmodium-falciparum-parasitized red blood cells in microcirculation

D.A. Fedosov, B. Caswell, S. Suresh and G.E. Karniadakis, PNAS, 108 (2011) 35-39. (supplementary materials; movie #1; movie #2; movie #3)

Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

Y.-K. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh and M.S. Feld, Journal of Biomedical Optics 2010, 15(2): 020506.

Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease

M. Diez-Silva, M. Dao, J. Han, C.-T. Lim and S. Suresh, MRS Bulletin, 35 (2010) 382-388.
==> see MRS Bulletin Cover Image

Febrile temperature leads to significant stiffening of Plasmodium falciparum parasitized erythrocytes

M. Marinkovic, M. Diez-Silva, I. Pantic, J.J. Fredberg, S. Suresh and J.P. Butler, Am J Physiol Cell Physiol, 296: C59 - C64, 2009.

Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum

Y.K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M.S. Feld and S. Suresh, PNAS, 105(37) 13730-13735, 2008.
==> see MIT News Report

Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum

J.P. Mills, M. Diez-Silva, D.J. Quinn, M. Dao, M.J. Lang, K.S.W. Tan, C.T. Lim, G. Milon, P.H. David,
O. Mercereau-Puijalon, S. Bonnefoy and S. Suresh, PNAS, 104(22) 9213-9217, 2007.

Molecularly based analysis of deformation of spectrin network and human erythrocyte

M. Dao, J. Li and S. Suresh, Mat Sci Eng C (26) 1232-1244, 2006.

Mechanical response of human red blood cells in health and disease: Some structure-property-function relationships

S. Suresh, Journal of Materials Research, 21 (8), 1871-1877, 2006.

Continuous force-displacement relationships for the human red blood cell at different erythrocytic developmental stages of Plasmodium falciparum malaria parasite

J. Mills, L. Qie, M. Dao, K. S.W. Tan, C. T. Lim and S. Suresh, Mater. Res. Soc. Symp. Proc., 844, Y7.8, 2005.

Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria

S. Suresh, J. Spatz, J.P. Mills, A. Micoulet, M. Dao, C.T. Lim, M. Beil and T. Sefferlein, Acta Biomaterialia , 1, 16-30, 2005.