An interdisciplinary, international group of researchers has found new biophysical markers that could help improve the understanding of treatments for sickle cell disease.
Researchers used computer modeling to show how the spleen maintains the quality of red blood cells in the bloodstream. The findings may provide insights into conditions that lead to anemia.
Computer model finds slits in the spleen impose a “physical fitness test” on red blood cells.
Technique could enable 3-D printing of cellular structures for tissue engineering.
Low-amplitude repeated stretching can eliminate crystal defects in nanoscale metal parts.
S. Saito*, T. Ochiai, F. Yoshizawa and M. Dao*, Scientific Reports, 6 (2016) 34063.
P. Hosseini, S.Z. Abidi, E Du, D.P. Papageorgiou, Y. Choi, Y.-K. Park, J. Higgins, G.J. Kato, S. Suresh*, M. Dao*, Z. Yaqoob* and P.T.C. So, “Cellular Normoxic Biophysical Markers of Hydroxyurea Treatment in Sickle Cell Disease,” Proc. Natl. Acad. Sci. USA, 2016, doi:10.1073/pnas.1610435113. (See Medical Xpress, News Medical, ScienceDaily, and CMU News Report)
X. Li , M. Dao , C. Eberl , A.M. Hodge and H. Gao, MRS Bulletin, 41 (2016) 298-304.